Taking PALSONIFY
PALSONIFY is a once-daily oral treatment for acromegaly
Take it once a day. That’s it. No injections. No surprises.
PALSONIFY is designed to treat acromegaly all day
The recommended initial dose is
40 mg
- PALSONIFY is 2 pills taken together once a day. Take PALSONIFY with water, on an empty stomach (after not eating overnight or for at least 6 hours). For example, you could take PALSONIFY before breakfast in the morning
- After taking PALSONIFY, wait at least 1 hour before eating or drinking anything other than water
- Take PALSONIFY at the same time every day to help you get the most out of your treatment
After taking 40 mg of PALSONIFY once daily for 2 to 4 weeks, your doctor may adjust your dose to 60 mg once daily (two 30-mg tablets) if needed
It’s designed to work with your body
- PALSONIFY is specifically made to be a once-daily oral treatment that’s absorbed efficiently through your digestive system—unlike injections
- PALSONIFY is designed to stay active in your body for over 24 hours, which helps maintain a steady level of medicine throughout the day with just one daily dose
- Taking it on an empty stomach helps your body absorb it fully, so it works the way it’s meant to
People stick with it
- At the end of the 36-week clinical study, more than 90% of people chose to take PALSONIFY instead of going back to injections
- In the same clinical study, almost everyone taking PALSONIFY stayed on track with their treatment
PALSONIFY side effects
For people who switched from injections:
Most side effects in the clinical study were mild to moderate, stomach related, and similar to those seen with other acromegaly treatments.*
Here’s what some people experienced:
- Diarrhea (23%)
- Nausea (13%)
- Loss of appetite (10%)
- Irregular heartbeat (palpitations) (7%)
- Stomach bug–like symptoms (gastroenteritis) (7%)
Stomach-related side effects, like diarrhea and nausea, resolved without stopping PALSONIFY.
*PALSONIFY was evaluated in two phase 3 clinical trials. Results are from study 2, which followed 58 people switching from injections.
For people new to or restarting treatment:
Here’s what some people experienced:
- Diarrhea (33%)
- Stomach pain or discomfort (19%)
- Nausea (9%)
- Slow heart rate (bradycardia) (7%)
- High blood sugar (7%)
Stomach-related side effects, like diarrhea and nausea, generally resolved without stopping PALSONIFY.
*PALSONIFY was evaluated in two phase 3 clinical trials. Results are from study 1, which followed 111 people new to or restarting treatment.
Ready to ask your doctor about PALSONIFY?
Use this discussion guide to get the conversation going with your healthcare provider.
David, musician,
living with acromegaly
Start PALSONIFY with support
CrinetiCARE provides personalized support to help you navigate your treatment journey with PALSONIFY.
Whether you have questions about insurance coverage, need help finding a healthcare provider, or are seeking a nurse educator, CrinetiCARE is here to help.
PALSONIFY Welcome Kit
Treating acromegaly isn’t easy, and making a change takes courage. By choosing PALSONIFY, you’ve taken a meaningful step forward. Inside are tools to help you start strong. And through it all, we’re with you.
